Steven Baugh

Session Title: Pharmacognosy Practices in Creation of Edible Cannabis Medicine

Time: Feb 26th, 1:00 PM
Location: Seminar Room #3

Professional Summary

Mr. Baugh has a Master’s in Chemistry from Colorado School of Mines and over two decades of industry experience in extraction, analysis, quality assurance and regulatory compliance for the environmental, pharmaceutical, dietary supplement and cannabis industries. Mr. Baugh has managed two independent analytical laboratories through ISO17025 accreditation and has held the position of Senior Industrial Hygienist during his career. He has reviewed manuscripts for prestigious industry journals and has presented lectures and posters on analytical testing, regulatory compliance and quality assurance at industry trade shows, regulatory meetings and international conferences. 

Mr. Baugh holds three patents in extraction/analytical technology and has a patent-pending for chemometric visualization of chemical profiles with downstream applications. Mr. Baugh was a member of the AHPA Cannabis Committee, where he helped complete the recommendations for Analytical Laboratories.  Mr. Baugh’s extensive extraction, separation, analytical and regulatory compliance background allow him to quickly understand complex topics like extraction safety issues, FDA warning letters to the CBD market, FDA New Dietary Ingredient guidance and identifying potential compounds and mixtures for IND and NDA drug discovery studies.

Professional Highlights:

  • Patent awarded for novel air sampling cartridge
  • Patent awarded for novel Molecular Imprint Polymer solid-phase adsorbent
  • Patent awarded for modular, scalable freeze drier
  • J. AOAC Hypericin in St. John’s Wort analytical method published on PubMed
  • Redox Medicine Pioneer, US Patent Applications 20090023804 and 20100021989
  • Tea Chemistry presentation at the World Tea Expo, Las Vegas
  • Chaired the Antioxidant “Hot Topic” Section at the AOAC Annual Meeting, New Orleans
  • Taken two laboratories through the ISO17025 accreditation process
  • Audited by Federal, State and Local authorities; including EPA (Federal and various states), FDA (pharmaceutical and dietary supplements), DEA (Special Projects) and OSHA
  • Member of the AHPA Cannabis Committee and helped complete the Recommendations for Laboratories
  • Former butane extractor manufacturer and author of white papers on cannabis extraction safety issues including MAQs, pressures, safety factors and venting compressed gases.
  • Currently offering courses to the cannabis industry covering Extraction, Equipment Operation, Distillation, Chromatography, Recrystallizations and Data Interpretation
  • Harrington, PB, Baugh, SF, Anderson, DE and McChesney, JD (2016, April). A Novel Three-Dimensional Chemical Characterization and Visualization Tool Applied to Green Tea, Hops, and Cannabis Varieties. Oral Presentation at the 16 th Annual International Conference on the Science of Botanicals, Oxford, Mississippi.
  • SBaugh and PHarrington (2018, February). Non-targeted Chemical Characterization, Authentication, and Dosing of Complex Cannabis Medicines. Oral Presentation at the 2018 Emerald Conference, Novel Clinical Development Paradigms Session, San Diego, California.
  • Other presentations available upon request

Session Abstract

Introduction:

The Cannabis plant has been used by humans for thousands of years, and more recently for a host of ailments as approved by multiple States. There are different Cannabis medicines, and it is increasingly evident that the patient outcome depends on both the product consumed and the biochemical individuality of the patient. Early Cannabis success stories were linked to strains, or perhaps CBD versus THC, and are difficult to review due to the limited characterization of the products. Early attempts at product characterization pursued strains, then genetics: however, botany and genetics describe the plant, pharmacognosy strives to correlate patient outcomes to the chemicals they take as medicines. Chemical profiling allows the characterization of medicines while supporting the discovery of new active compounds, whether they are individual compounds or combinations. Cannabis research is at a crossroads; one well-beaten path leading to single compound drugs and the other trail-blazing path to properly characterized complex Cannabis mixtures. Properly characterized and standardized Cannabis medicines can then be correlated to patient outcomes.

Characterization Methods:

Morphological taxonomy is the oldest system of classifying plants. This system relies on the appearance of the plant- the shape, colors, and sizes of the leaves and other various plant parts. Sometimes, there is mention of what parts of the plant are medicinal, or when to harvest, but old scientific literature is about describing the looks of the plant to identify it. This classification system requires no special tools or instruments, but a camera or good drawing skills are required. For Cannabis there are three different botanical species; sativa, indica, and ruderalis. This classification system is popular with those who work directly with the plants, like growers and breeders.

Genetics as a science and analytical tool is a recent advance and requires sophisticated technologies and equipment. This tool further characterizes the plant by studying the genetic sequence, or the genotype. Environmental factors cause different genes to express and may affect the plant’s resulting size, shape, color- commonly called the phenotype. Phenotypes are often used to describe differences in morphology, behavior, development, and even different biochemical or physiological properties.

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